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Vioxx Side Effects Were Known Four Years Ago Says U.K. Medical Journal
Merck should have been aware of Vioxx heart attack and stroke side effects at least four years ago. This shocking information was recently published in the Lancet and is based on 29 separate studies, which highlighted the risks for patients using Vioxx.The report's conclusions were based on studies published in scientific journals as well as unpublished data from the United States Food and Drug Administration, which was obtained under the Freedom of Information Act. Merck issued a worldwide recall of Vioxx in late September.
The Lancet report criticized Merck's interpretation of an earlier study, which compared Vioxx to naproxen, also known as Alleve in the United States. While heart attacks were at least four times more frequent for Vioxx users than naproxen users, Merck claimed this was due to naproxen having a protective effect on the heart. But researchers said their work showed that there was no evidence of that naproxen had any beneficial effect on the heart.
The report also disputed Merck's claim that Vioxx heart attack risk was only associated people taking larger dosages for 18 months or more. However, the researchers showed that the risks of Vioxx were present irrespective of the dosage or period of use. Even small doses of Vioxx were associated with a risk of myocardial infarction.
Vioxx Recall Timeline
Documents May Show Merck Knew About Vioxx Side Effects
Vioxx
Vioxx FDA Information
Where does this come from?
VIOXX (Rofecoxib) FDA INFORMATION
The FDA issued several warnings concerning Vioxx related side effects before the drug was removed from the market.. The links below will redirect you to these warnings on the FDA website.
- 2001 Merck Vioxx VIGOR Study
- 2001 Vioxx Advertising Warning Letter
- 2002 FDA Vioxx Talk Paper
- 2002 Merck Vioxx Dear Doctor Letter
- 2002 Vioxx Safety Label Update
- 2004 FDA Vioxx Recall Advisory
- 2004 FDA Vioxx COX II Q&A
- 2004 FDA Statement on Vioxx
- 2004 FDA Vioxx David Graham Statement
- 2004 Vioxx- Drug Safety Controversy
- 2005 FDA Vioxx Timeline
- 2005 FDA-Vioxx Cardiovascular Safety
Quick Facts
Vioxx Reference Guide
Generic Name
Rofecoxib
Date Approved
May 20, 1999
Manufacturer
Merck & Co.
Status
Withdrawn 9/30/04
Approved Uses
Arthritis
Muscle pain
Off Label Uses
Bone pain
Muscle pain
General pain
Serious Side Effects
Heart attacks
Blood clots
Stroke
Related Topics
Bextra
Celebrex
Mobic
Blood Clots
Heart Attacks
Stroke
Defective Drugs
Diseases
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