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Toxic Epidermal Necrolysis


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Toxic Epidermal Necrolysis (TEN)

Toxic epidermal necrolysis (TEN) is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to disengage from the layers of skin below. Toxic epidermal necrolysis (TEN) begins with fever, cough and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes.

These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis.

The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine, antibiotics such as aminopenicillins and cephalosporins, and anticonvulsants like phenytoin. EN is extremely rare. Researchers estimate that there are 0.2 cases per million users of aminopenicillins and 4.5 cases per million users of sulfonamides.

People with TEN seem to have difficulty metabolizing the offending drug. Some researchers suggest that certain substances that should be cleared from the body instead get deposited on the outer shell of the epidermis, causing an immune response that leads the body to "reject" the skin.

About 25-30% of patients with TEN die. Elderly patients, those with extensive skin lesions, and those with AIDS have the worst prognosis. Widespread systemic infection (sepsis) is the primary cause of death.

If you or a loved one have taken prescription and/or over the counter drugs and has been diagnosed with Toxic Epidermal Necrolysis (TEN), please fill out the form at the right for a free case evaluation by a qualified drug side effects attorney.

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Revlimid Linked to Steven-Johnson Syndrome, Toxic Epidermal Necrolysis

Sep 19, 2008 | Parker Waichman Alonso LLP
Revlimid, a blood cancer drug made by Celgene Corp., has been associated with Stevens-Johnson Syndrome and toxic epidermal necrolysis, serious and potentially fatal skin disorders. A spokesperson for Celgene told The Wall Street Journal that it  is likely the label for Revlimid would be updated in the future to include reports of the skin reactions.Revlimid was the first of Celgene's new class of oral cancer drugs called IMiDs (immunomodulatory drug). IMiDs modify or regulate the...

Sinus drug linked to liver damage, skin peeling

May 7, 2007 | Vancouver Sun
Somewhere near Quebec City lives a young mother who spent four weeks in a burn unit last year after a suspected drug reaction covered her body with burn-like red blisters and peeled off her skin from head to thigh. The woman had been prescribed the antibiotic Ketek for a simple sinus infection. But the 26-year-old developed toxic epidermal necrolysis, an extremely rare drug reaction where people essentially shed the outer protective layer of their skin. The woman was found semi-conscious...

Lawsuit Claims Children's Motrin Causes Severe Side-Effects

Dec 28, 2003 | AP
The parents of a 7-year-old girl Tuesday sued the makers of Children's Motrin and several other companies that distribute it, claiming their daughter lost her eyesight and suffered other severe side effects after taking the medication.The lawsuit, filed on behalf of Sabrina Brierton Johnson of Los Angeles, seeks unspecified compensatory and punitive damages against health care giant Johnson & Johnson, subsidiary McNeil Consumer & Specialty Pharmaceuticals, and several other firms, including...

Without Warning

Apr 10, 2003 | www.metroactive.com
A rare but debilitating and potentially deadly allergic reaction to some drugs, may be on the rise. But you won't read about it on drug labels.KAITLYN LANGSTAFF'S catastrophic injuries are the stuff of nightmares. In 12 months, this 9-year-old girl from Saratoga has gone from being active and healthy to wheelchair-bound, blind and unable to eat or speak. With massive scarring in her lungs and airways, she breathes bottled oxygen through a tube inserted in her neck. She relies on a feeding tube...

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